Ligand to Hold Third Quarter Results Conference Call on November 8

SAN DIEGO--

Ligand Pharmaceuticals Incorporated (NASDAQ:LGND) announced today that it plans to report third quarter 2007 financial results on Thursday, November 8, 2007 following the close of market. Ligand's President and CEO, John L. Higgins and Vice President of Finance and CFO, John P. Sharp will host the conference call.

What:                Ligand Pharmaceuticals conference call to discuss
                      financial results and provide general business
                      updates.

When:                Thursday, November 8, 2007

Time:                1:30 p.m. Pacific time (4:30 p.m. Eastern time)

Webcast:             Conference call and replay accessible at
                      www.ligand.com.

Conference Call:     (877) 356-5578, ID # 22432883 (U.S.)
                     (706) 679-0565, ID # 22432883 (outside the U.S)

Replay:              (800) 642-1687, ID # 22432883 (U.S.)
                     (706) 645-9291, ID # 22432883 (outside the U.S.)
                     Replay of conference call will be available from
                      November 8, 2007 to December 8, 2007.

About Ligand Pharmaceuticals

Ligand discovers and develops new drugs that address critical unmet medical needs of patients in the areas of thrombocytopenia, hepatitis C, cancer, hormone-related diseases, osteoporosis and inflammatory diseases. Ligand's proprietary drug discovery and development programs are based on its leadership position in gene transcription technology, primarily related to intracellular receptors.

Source: Ligand Pharmaceuticals Incorporated

Released November 1, 2007