Annual report pursuant to Section 13 and 15(d)

Fair Value Measurement - Unobservable Inputs (Details)

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Fair Value Measurement - Unobservable Inputs (Details) - CyDex
12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Revenue volatility (as a percent) 25.00% 25.00%
Average of probability of commercialization (as a percent) 12.50% 12.50%
Market price of risk (as a percent) 2.90% 3.20%