EXHIBIT 21.1


                  EXHIBIT 21.1 SUBSIDIARIES OF THE REGISTRANT

                      LIGAND PHARMACEUTICALS, INCORPORATED

                              LIST OF SUBSIDIARIES




<TABLE>
<CAPTION>
Name                                                             Jurisdiction of Incorporation 
- ----                                                             ----------------------------- 
<S>                                                              <C>
Glycomed Incorporated                                                     California

Ligand Pharmaceuticals, (Canada) Incorporated                             Saskatchewan, Canada

Allergan Ligand Retinoid Therapeutics, Inc.                               Delaware

Seragen Incoporated                                                       Massachusetts
</TABLE>