Exhibit 21.1

LIGAND PHARMACEUTICALS INCORPORATED
LIST OF SUBSIDIARIES


NameJurisdiction of Incorporation
Ab Initio Biotherapeutics, Inc.Delaware
Allergan Ligand Retinoid Therapeutics, Inc.Delaware
Cita NeuroPharmaceuticals Inc.Canada
Crystal Bioscience, Inc.California
CyDex Pharmaceuticals, Inc.         Delaware
Glycomed Incorporated                 California
Icagen, LLCDelaware
Ligand Biopharmaceuticals IncorporatedDelaware
Ligand JVR, Inc.Delaware
Ligand Pharmaceuticals (Canada) IncorporatedCanada
Ligand Pharmaceuticals International, Inc.Delaware
Ligand Pharmaceuticals UK LimitedUnited Kingdom
Metabasis Therapeutics, Inc.Delaware
Neurogen CorporationDelaware
OMT I, Inc.Delaware
OMT II, Inc.Delaware
OMT, LLCDelaware
Open Monoclonal Technology, Inc.Delaware
Pfenex Inc.Delaware
Pharmacopeia, LLCDelaware
Seragen IncorporatedDelaware
Seragen Technology, Inc.Delaware
Taurus Biosciences, LLC
Delaware
Vernalis (Canada II) Inc.Canada
Vernalis (Canada) Inc.Canada
Vernalis Development LimitedEngland and Wales
Vernalis Group LimitedEngland and Wales
Vernalis plcEngland and Wales
Vernalis Research LimitedEngland and Wales
Vernalis Therapeutics Inc.Delaware
xCella Biosciences, Inc.
Delaware