Exhibit 21.1

LIGAND PHARMACEUTICALS INCORPORATED
LIST OF SUBSIDIARIES


NameJurisdiction of Incorporation
Ab Initio Biotherapeutics, Inc.Delaware
Adjacent Acquisition Co., LLCDelaware
Glycomed Incorporated     California
Allergan Ligand Retinoid Therapeutics, Inc.Delaware
Ligand Pharmaceuticals International, Inc.Delaware
Ligand Biopharmaceuticals IncorporatedDelaware
Ligand JVR, Inc.Delaware
Ligand Pharmaceuticals UK LimitedUnited Kingdom
Ligand Pharmaceuticals (Canada) IncorporatedCanada
Seragen IncorporatedDelaware
Seragen Technology, Inc.Delaware
Pharmacopeia, LLCDelaware
Metabasis Therapeutics, Inc.Delaware
Neurogen CorporationDelaware
CyDex Pharmaceuticals, Inc.   Delaware
Open Monoclonal Technology, Inc.Delaware
OMT I, Inc.Delaware
OMT II, Inc.Delaware
Crystal Bioscience, Inc.California
Vernalis plcEngland and Wales
Vernalis (R&D) LimitedEngland and Wales
Vernalis Group LimitedEngland and Wales
Vernalis Therapeutics Inc.Delaware
Vernalis (Canada) Inc.Canada
Vernalis (Canada II) Inc.Canada
Vernalis Development LimitedEngland and Wales
Vernalis Research LimitedEngland and Wales
Cita NeuroPharmaceuticals Inc.Canada