Balance Sheet Account Details - Contingent Liabilities (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Contingent Liability [Roll Forward]
Commercial rights, beginning of period	$ 3,707	$ 41,929
Payments	0	(50)
Fair Value Adjustment	(194)	(38,172)
Repurchases	0
Commercial rights, end of period	3,513	3,707
Cydex
Contingent Liability [Roll Forward]
Commercial rights, beginning of period	349	507
Payments	0	(50)
Fair Value Adjustment	(265)	(108)
Repurchases	0
Commercial rights, end of period	84	349
Metabasis
Contingent Liability [Roll Forward]
Commercial rights, beginning of period	3,358	3,822
Payments	0	0
Fair Value Adjustment	71	(464)
Repurchases	0
Commercial rights, end of period	3,429	3,358
Pfenex
Contingent Liability [Roll Forward]
Commercial rights, beginning of period	0	37,600
Payments	0	0
Fair Value Adjustment	0	(37,600)
Repurchases	0
Commercial rights, end of period	$ 0	$ 0