Quarterly report pursuant to Section 13 or 15(d)

Basis of Presentation and Summary of Significant Accounting Policies - Narrative (Details)

Basis of Presentation and Summary of Significant Accounting Policies - Narrative (Details) shares in Thousands	3 Months Ended		9 Months Ended		12 Months Ended
	Sep. 30, 2022 USD ($) position shares	Sep. 30, 2021 USD ($) shares	Sep. 30, 2022 USD ($) position reporting_unit shares	Sep. 30, 2021 USD ($) shares	Dec. 31, 2021 USD ($) reporting_unit	Jun. 30, 2022 USD ($)	Mar. 31, 2022 USD ($)	Jun. 30, 2021 USD ($)	Mar. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)
Property, Plant and Equipment [Line Items]
Decrease of deferred tax liabilities	$ (29,832,000)		$ (29,832,000)		$ (59,095,000)
Decrease (increase) of stockholders' equity	(816,298,000)	$ (812,066,000)	(816,298,000)	$ (812,066,000)	(821,159,000)	$ (802,365,000)	$ (793,192,000)	$ (786,517,000)	$ (745,840,000)	$ (709,525,000)
Revenue recognized that was previously deferred	$ 4,100,000	$ 7,700,000	$ 8,800,000	$ 22,800,000
Number of positions in an unrealized loss position \| position	8		8
Credit losses related to available-for-sale debt securities	$ 0		$ 0
Allowance for credit losses adjustment related to COVID-19	(100,000)		(300,000)
Inventory	$ 22,326,000		$ 22,326,000		$ 27,326,000
Number of reporting units \| reporting_unit			2		1
Potentially dilutive shares excluded from calculation due to anti-dilutive effect (in shares) \| shares	6,706	5,574	6,503	4,984
Share-based Compensation
Property, Plant and Equipment [Line Items]
Potentially dilutive shares excluded from calculation due to anti-dilutive effect (in shares) \| shares			300
Restricted Stock Awards
Property, Plant and Equipment [Line Items]
Performance period for awards			3 years
Restricted Stock Awards \| Minimum
Property, Plant and Equipment [Line Items]
Payout range (as a percent)			0.00%
Restricted Stock Awards \| Maximum
Property, Plant and Equipment [Line Items]
Payout range (as a percent)			200.00%
Captisol
Property, Plant and Equipment [Line Items]
Inventory	$ 7,400,000		$ 7,400,000		$ 24,600,000
Adjustment
Property, Plant and Equipment [Line Items]
Decrease (increase) of stockholders' equity					15,997,000
Adjusted Balance
Property, Plant and Equipment [Line Items]
Increase of carrying amount of Notes					341,100,000
Unamortized discount					2,200,000
Accounting Standards Update 2020-06
Property, Plant and Equipment [Line Items]
Potentially dilutive shares excluded from calculation due to anti-dilutive effect (in shares) \| shares	600		1,100
Accounting Standards Update 2020-06 \| Adjustment
Property, Plant and Equipment [Line Items]
Increase of carrying amount of Notes					20,400,000
Decrease of deferred tax liabilities					4,400,000
Additional paid in capital
Property, Plant and Equipment [Line Items]
Decrease (increase) of stockholders' equity	$ (348,994,000)	$ (358,418,000)	$ (348,994,000)	$ (358,418,000)	(372,969,000)	(335,471,000)	(325,368,000)	(346,578,000)	(336,621,000)	(318,358,000)
Additional paid in capital \| Adjustment
Property, Plant and Equipment [Line Items]
Decrease (increase) of stockholders' equity					51,130,000
Additional paid in capital \| Accounting Standards Update 2020-06 \| Adjustment
Property, Plant and Equipment [Line Items]
Decrease (increase) of stockholders' equity					51,100,000
Retained earnings
Property, Plant and Equipment [Line Items]
Decrease (increase) of stockholders' equity	$ (468,347,000)	$ (454,506,000)	$ (468,347,000)	$ (454,506,000)	(449,090,000)	$ (467,943,000)	$ (468,838,000)	$ (440,783,000)	$ (410,058,000)	$ (391,952,000)
Retained earnings \| Adjustment
Property, Plant and Equipment [Line Items]
Decrease (increase) of stockholders' equity					(35,133,000)
Retained earnings \| Accounting Standards Update 2020-06 \| Adjustment
Property, Plant and Equipment [Line Items]
Decrease (increase) of stockholders' equity					$ (35,100,000)