Annual report pursuant to Section 13 and 15(d)

Income Taxes - Reconciliation of Income Tax Expense (Benefit) (Details)

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Income Taxes - Reconciliation of Income Tax Expense (Benefit) (Details) - USD ($)
$ in Thousands
3 Months Ended 12 Months Ended
Dec. 31, 2020
Sep. 30, 2020
Jun. 30, 2020
Mar. 31, 2020
Dec. 31, 2019
Sep. 30, 2019
Jun. 30, 2019
Mar. 31, 2019
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Income Tax Expense (Benefit), Continuing Operations, Income Tax Reconciliation [Abstract]                      
Tax at federal statutory rate                 $ (2,213) $ 167,294 $ 36,400
State, net of federal benefit                 (1,456) 2,466 1,635
Contingent liabilities                 (278) 18 948
Share-based compensation                 (362) (819) (8,131)
FDII                 (1,652) (402) 0
Research and development credits                 (699) (879) (2,758)
Change in uncertain tax positions                 (650) 441 858
Rate change for changes in federal or state law                 (173) (210) 178
Provision to return adjustments                 (4,803) (184) (150)
Foreign tax differential on income/loss of foreign subsidiaries                 (3,839) 57 (14)
Change in valuation allowance                 (121,876) (1,193) (4,225)
Sale of Vernalis R&D                 127,372 0 0
Expired NOLs and credits                 0 0 3,054
Change in derivatives                 0 0 615
Other                 3,076 748 1,599
Income tax expense from continuing operations $ (2,391) $ (4,911) $ 6,033 $ (6,284) $ (810) $ (4,620) $ (3,609) $ 176,376 $ (7,553) $ 167,337 $ 30,009