Quarterly report pursuant to Section 13 or 15(d)

Basis of Presentation and Summary of Significant Accounting Policies - Accounting for Share-Based Compensation (Details)

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Basis of Presentation and Summary of Significant Accounting Policies - Accounting for Share-Based Compensation (Details) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2019
Sep. 30, 2018
Sep. 30, 2019
Sep. 30, 2018
Basis of Presentation [Line Items]        
Share-based compensation expense $ 6,297 $ 5,470 $ 18,215 $ 14,837
Research and development expenses        
Basis of Presentation [Line Items]        
Share-based compensation expense 2,481 2,257 7,136 6,120
General and administrative expenses        
Basis of Presentation [Line Items]        
Share-based compensation expense $ 3,816 $ 3,213 $ 11,079 $ 8,717