Quarterly report pursuant to Section 13 or 15(d)

Basis of Presentation and Summary of Significant Accounting Policies - Accounting for Share-Based Compensation (Details)

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Basis of Presentation and Summary of Significant Accounting Policies - Accounting for Share-Based Compensation (Details) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2019
Mar. 31, 2018
Basis of Presentation [Line Items]    
Share-based compensation expense $ 5,347 $ 4,555
Research and development expenses    
Basis of Presentation [Line Items]    
Share-based compensation expense 2,127 1,767
General and administrative expenses    
Basis of Presentation [Line Items]    
Share-based compensation expense $ 3,220 $ 2,788