Annual report pursuant to Section 13 and 15(d)

Stockholders' Equity - Share-Based Compensation (Details)

v3.10.0.1
Stockholders' Equity - Share-Based Compensation (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Share-based compensation expense $ 20,846 $ 24,915 $ 18,893
Research and development expenses      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Share-based compensation expense 8,352 14,235 8,836
General and administrative expenses      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Share-based compensation expense $ 12,494 $ 10,680 $ 10,057