Annual report pursuant to Section 13 and 15(d)

Basis of Presentation and Summary of Significant Accounting Policies - Revenue by Source (Details)

v3.10.0.1
Basis of Presentation and Summary of Significant Accounting Policies - Revenue by Source (Details) - USD ($)
$ in Thousands
3 Months Ended 12 Months Ended
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2017
Sep. 30, 2017
Jun. 30, 2017
Mar. 31, 2017
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Disaggregation of Revenue [Line Items]                      
Total revenues $ 50,465 $ 33,375 $ 27,995 $ 29,267 $ 59,590 $ 45,663 $ 90,043 $ 56,157 $ 251,453 $ 141,102 $ 108,973
Material sales                      
Disaggregation of Revenue [Line Items]                      
Total revenues                 29,123 22,070 22,502
License fees, milestones and other revenues                      
Disaggregation of Revenue [Line Items]                      
Total revenues                 93,774 30,347 27,048
License fees                      
Disaggregation of Revenue [Line Items]                      
Total revenues                 78,195 13,665 10,570
Milestones                      
Disaggregation of Revenue [Line Items]                      
Total revenues                 6,577 11,093 16,091
Other                      
Disaggregation of Revenue [Line Items]                      
Total revenues                 $ 9,002 $ 5,589 $ 387