EX-2.1 OTHERDOC
      Statement of Control Person

                                                                     Exhibit 2.1
                                                                     ----------

                             Statement of Control Person


The Statement on this Schedule 13G dated November 29, 2002 with respect to the
common stock par value $0.001 per share of Ligand Pharmaceuticals Incorporated
is filed by Samuel D. Isaly in accordance with the provisions of Rule 13d-1(c)
and Rule 13d-1(k) respectively as a control person (HC) of Orbimed Advisors LLC
and Orbimed Advisors Inc.

Orbimed Advisors Inc. and OrbiMed Advisors LLC file this statement on Schedule
13G in accordance with the provisions of Rule 13d-1(b) and Rule 13d-1(k)
respectively as investment advisors (IA).