Document

Exhibit 21.1

LIGAND PHARMACEUTICALS INCORPORATED
LIST OF SUBSIDIARIES

NameJurisdiction of Incorporation
Ab Initio Biotherapeutics, Inc.Delaware
Allergan Ligand Retinoid Therapeutics, Inc.Delaware
Cita NeuroPharmaceuticals Inc.Canada
Crystal Bioscience, Inc.California
CyDex Pharmaceuticals, Inc.         Delaware
Glycomed Incorporated                 California
Icagen, LLCDelaware
Ligand Biopharmaceuticals IncorporatedDelaware
Ligand Holdings UK LimitedEngland and Wales
Ligand JVR, Inc.Delaware
Ligand Pharmaceuticals (Canada) IncorporatedCanada
Ligand Pharmaceuticals International, Inc.Delaware
Ligand Pharmaceuticals UK LimitedUnited Kingdom
Ligand UK Development LimitedEngland and Wales
Ligand UK Group LimitedEngland and Wales
Ligand UK LimitedEngland and Wales
Ligand UK Research LimitedEngland and Wales
Metabasis Therapeutics, Inc.Delaware
Neurogen CorporationDelaware
OmniAb, Inc.Delaware
OMT I, Inc.Delaware
OMT II, Inc.Delaware
Pfenex Inc.Delaware
Pharmacopeia, LLCDelaware
Seragen IncorporatedDelaware
Seragen Technology, Inc.Delaware
Taurus Biosciences, LLC
Delaware
Vernalis Therapeutics Inc.Delaware
xCella Biosciences, Inc.
Delaware