Quarterly report pursuant to Section 13 or 15(d)

Basis of Presentation and Summary of Significant Accounting Policies (Accounting for Share-Based Compensation) (Details)

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Basis of Presentation and Summary of Significant Accounting Policies (Accounting for Share-Based Compensation) (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2017
Jun. 30, 2016
Jun. 30, 2017
Jun. 30, 2016
Basis of Presentation [Line Items]        
Share-based compensation expense total $ 4,624 $ 4,647 $ 10,669 $ 8,766
Research and development expenses        
Basis of Presentation [Line Items]        
Share-based compensation expense total 1,928 2,089 5,867 3,674
General and administrative expenses        
Basis of Presentation [Line Items]        
Share-based compensation expense total $ 2,696 $ 2,558 $ 4,802 $ 5,092