Quarterly report pursuant to Section 13 or 15(d)

Basis of Presentation and Summary of Significant Accounting Policies (Accounting for Share-Based Compensation) (Details)

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Basis of Presentation and Summary of Significant Accounting Policies (Accounting for Share-Based Compensation) (Details) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2017
Mar. 31, 2016
Basis of Presentation [Line Items]    
Share-based compensation expense total $ 6,045 $ 4,118
Research and development expenses    
Basis of Presentation [Line Items]    
Share-based compensation expense total 3,939 1,585
General and administrative expenses    
Basis of Presentation [Line Items]    
Share-based compensation expense total $ 2,106 $ 2,533