Annual report pursuant to Section 13 and 15(d)

Stockholders' Equity - Share-base Compensation (Details)

v3.6.0.2
Stockholders' Equity - Share-base Compensation (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Share-based compensation expense $ 18,893 $ 12,458 $ 11,270
Research and development expenses      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Share-based compensation expense 8,836 4,080 3,595
General and administrative expenses      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Share-based compensation expense $ 10,057 $ 8,378 $ 7,675